LD3 isoenzyme may be increased in which condition?

LD3 isoenzyme may be increased in which condition?

• A. Pancreatitis
• B. Hepatic damage
• C. Myocardial infarction
• D. Hemolytic anemia

Answer: (A)

Lactate dehydrogenase (LDH) has five isoenzymes that reflect different tissue sources, so changes in which isoenzyme is elevated can point to where tissue damage is occurring. LDH-3 is relatively abundant in pancreas tissue, so when pancreatic cells are damaged as in pancreatitis, LDH-3 tends to rise in the serum. This pattern helps distinguish pancreatitis from other conditions: myocardial infarction more commonly increases LDH-1 and LDH-2, hepatic damage often shifts toward LDH-5 (with some LDH-4), and hemolytic anemia mainly elevates LDH-1 and LDH-2 due to red blood cell destruction. Therefore, an increase in LD-3 aligns best with pancreatitis.

Lactate dehydrogenase (LDH) has five isoenzymes that reflect different tissue sources, so changes in which isoenzyme is elevated can point to where tissue damage is occurring. LDH-3 is relatively abundant in pancreas tissue, so when pancreatic cells are damaged as in pancreatitis, LDH-3 tends to rise in the serum. This pattern helps distinguish pancreatitis from other conditions: myocardial infarction more commonly increases LDH-1 and LDH-2, hepatic damage often shifts toward LDH-5 (with some LDH-4), and hemolytic anemia mainly elevates LDH-1 and LDH-2 due to red blood cell destruction. Therefore, an increase in LD-3 aligns best with pancreatitis.